Human evolution
Long before Charles Darwin caused a major uproar with his theory of evolution, da Vinci had pretty much the same idea. In fact, he apparently just took the idea that humans had evolved from apes as a given and didn’t even really try to argue it.
According to The Guardian, da Vinci’s study of comparative anatomy allowed him to observe the close relation of the two species.
As part of an outline for a book about anatomy, he wrote about “the description of man, which includes that of such creatures as are almost of the same species, as Apes, Monkeys and the like, which are many.”